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A complete of 3 % of Energetic compound is excreted in urine as unchanged active material. Tapentadol is Furthermore metabolised to N-desmethyl tapentadol (thirteen %) by CYP2C9 and CYP2C19 and to hydroxy tapentadol (2 %) by CYP2D6, which are further metabolised by conjugation. As a result, Lively substance metabolism mediated by cytochrome P450 te